Addressing the threat of Antimalarial drug resistance.
Since 2000, 2.3 billion cases and 14 million deaths have been averted. To date, 47 countries have been certified malaria-free (of which two in 2024 and three in 2025), while 37 countries reported fewer than 1000 cases in 2024. Success is possible, even in tough areas: The Greater Mekong Subregion proves elimination is achievable, with cases falling by nearly 90% despite long-standing drug resistance. Between 2000 and 2024, the number of malaria-endemic countries fell sharply, dropping from 108 to 80. Over the same period:Countries with fewer than 10 000 cases rose from 27 in 2000 to 46 in 2024. Countries with fewer than 100 indigenous cases increased from 6 to 26. Countries with fewer than 10 indigenous cases increased from 4 to 24. But the global situation is stalling: In 2024, there were an estimated 282 million cases and 610,000 deaths—a slight increase from 2023. According to the World Malaria Report 2025 , progress is at risk:Biological challenges: Drug resistance : Artemisinin pa...